Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor

Purpose: Some anesthetic drugs are known to have influence on circulation due hemorheological effects.We aimed investigate the possible effects of ketamin-xylazine anesthesia, which is extensively used inexperimental animal laboratories parameters.Materials and methods: Adult, male Wistar-Albino rats were divided into two as control (pre-anesthesia)and post-anesthesia (n=17). Ketamin-HCl/Xylazine-HCl (90 mg/kg-10 mg/kg) injected intraperitoneally.Intracardiac heparinized blood was collected either without anesthesia (control group) or after anesthesia(post-anesthesia following loss reflexes such righting, cornea withdrawal. Erythrocytedeformability determined by an ektacytometer, while WBV (at shear rates 38, 76 190 s-1) PV(at s-1 rate) at standard (40%) otolog hematocrit (Hct) measured via a cone-plate rotationalviscometer.Results: Mean time taken for disappearance righting reflex 4±3.6, corneal 8±6.8 forwithdrawal 10±6.7 min. 90 mg/kg Ketamin-10 Xylazine administration did not affect RBCdeformability, PV rats.Conclusion: These results demonstrate that, use Ketamin/Xylazine may be recommendedespecially when dealing with hemorheological, cardiovascular hematological parameters.